Nanomaterials and Nanosystems for Biomedical Applications
Abstract During the past decades, functionalized nano-systems were believed in holding the bright future of the nanomaterials in biomedical applications. Keywords Functional peptide. Recommended articles Citing articles 0.
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All rights reserved. Exploitation of lignin in nanoparticulate morphology is a potential method to prepare bionanomaterials for advanced applications. Molecular masses were analyzed also for the CLPs prepared from the enzymatically treated lignins.
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The smaller values of dissolved CLPs are most likely due to slower solubility of CLPs in alkaline reaction conditions than powdered lignin. In both cases, the protein coating following enzymatic cross-linking was performed at 3. Enzyme activity was removed using ultracentrifugation following redispersion of the particles at above pH. All force profiles were normalized with the radius of the probe. Adhered strips subjected to a controlled tension until failure below. Abstract Curcumin is a promising anti-cancer drug, but its applications in cancer therapy are limited, due to its poor solubility, short half-life and low bioavailability.
Curcumin is a promising anti-cancer drug, but its applications in cancer therapy are limited, due to its poor solubility, short half-life and low bioavailability. Alginate and chitosan were deposited on Fe 3 O 4 magnetic nanoparticles based on their electrostatic properties. The nanoparticle size ranged from — nm, within the optimum range for drug delivery. Controllable and sustained release of curcumin was obtained by altering the number of chitosan and alginate layers on the nanoparticles. Confocal fluorescence microscopy results showed that targeted delivery of curcumin with the aid of a magnetic field was achieved.
The fluorescence-activated cell sorting FACS assay indicated that MDA-MB cells treated with curcumin loaded nanoparticles had a 3—6 fold uptake efficiency to those treated with free curcumin. The sustained release profiles, enhanced uptake efficiency and cytotoxicity to cancer cells, as well as directed targeting make MACPs promising candidates for cancer therapy.
Zeta potential of particles was analysed in water pH 7 and phosphate solution 10 mM, pH 7. Particle size was analysed in phosphate solution. The CUR uptake was analysed by flow cytometry. The alternative coating was repeated until MACPs with desired number of layers were obtained Stage 2 and 3. Abstract The synthesis of ultrasmall UiO nanoparticles NPs with an average size of 25 nm, determined by X-ray powder diffraction and electron microscopies analysis, is reported. DLS [ The synthesis of ultrasmall UiO nanoparticles NPs with an average size of 25 nm, determined by X-ray powder diffraction and electron microscopies analysis, is reported.
DLS measurements confirmed the presence of particles of nm, which are spherical aggregates of smaller particles of 20—30 nm size. UV-vis spectroscopy analysis revealed no acridine loss after 48 h of agitation in simulated body fluid. The internalization process was evident after a few hours of incubation.
These data suggest that small UiO are biocompatible NP and could represent a potential carrier for drug delivery in glioblastoma therapies. Fluorescent cells accounts for Right panels represent propidium iodide staining showing cell cycle profiles. Numbers inside the gates represent percentage of apoptotic U cells assessed by propidium iodide staining. Blots are representative of at least three experiments. The difference in phoAkt level is not statistically significant.
Abstract A large number of deaths from cancer can be attributed to the lack of effective early-stage diagnostic techniques. Thus, accurate and effective early diagnosis is a major research goal worldwide. With the unique phenomenon of localized surface plasmon resonance LSPR , plasmonic nanomaterials have [ A large number of deaths from cancer can be attributed to the lack of effective early-stage diagnostic techniques. With the unique phenomenon of localized surface plasmon resonance LSPR , plasmonic nanomaterials have attracted considerable attention for applications in surface-enhanced Raman scattering SERS and metal-enhanced fluorescence MEF.
The gold nanoparticles are used as LSPR substrates to realized enhancement of Raman or fluorescence signal, while the gold nanoclusters serve as a fluorophore for MEF imaging, and exhibit better biocompatibility and stability. Furthermore, target molecule of cyclic Arg-Gly-Asp cRGD is incorporated into the composite to improve delivery efficiency, selectivity and imaging accuracy.
These integrated properties endow AuNPC-RGD composites with outstanding biocompatibility and excellent imaging abilities, which could be used to achieve accurate and effective diagnosis for early cancer. Hoechst and AuNPC were excited at the same wavelength of nm, and the fluorescence images were taken at — and — nm, respectively. Abstract The heterogeneity of breast cancer and the development of drug resistance are the relapse reasons of disease after chemotherapy.
To address this issue, a combined therapeutic strategy was developed by building the nanostructured dihydroartemisinin plus epirubicin liposomes. Investigations were performed on human breast [ The heterogeneity of breast cancer and the development of drug resistance are the relapse reasons of disease after chemotherapy. Investigations were performed on human breast cancer cells in vitro and xenografts in nude mice. The results indicated that dihydroartemisinin could significantly enhance the efficacy of epirubicin in killing different breast cancer cells in vitro and in vivo.
We found that the combined use of dihydroartemisinin with epirubicin could efficiently inhibit the activity of Bcl-2, facilitate release of Beclin 1, and further activate Bax. Besides, Bax activated apoptosis which led to the type I programmed death of breast cancer cells while Beclin 1 initiated the excessive autophagy that resulted in the type II programmed death of breast cancer cells. In addition, the nanostructured dihydroartemisinin plus epirubicin liposomes prolonged circulation of drugs, and were beneficial for simultaneously delivering drugs into breast cancer tissues.
Hence, the nanostructured dihydroartemisinin plus epirubicin liposomes could provide a new therapeutic strategy for treatment of breast cancer. The arrows indicate the day of drug administration. The nanostructured dihydroartemisinin plus epirubicin liposomes were internalized by cancer cells, escaped from the lysosomes, and existed in two states: the raptured and intact liposomes. Abstract The aim of this work was to investigate of biocompatibility of polymeric implants modified with silver nanoparticles AgNPs.
Middle ear prostheses otoimplants made of the poly acrylonitrile butadiene styrene ABS and ABS modified with silver nanoparticles were prepared through extrusion and injection moulding process. The aim of this work was to investigate of biocompatibility of polymeric implants modified with silver nanoparticles AgNPs.
The biocompatibility of the implants was evaluated in vivo on rats, after 4, 12, 24 and 48 weeks of implantation. The tissue-healing process and cytotoxicity of the implants were evaluated on the basis of microscopic observations of the materials morphology after histochemical staining with cytochrome c oxidase OCC and acid phosphatase AP , as well as via micro-tomography ex vivo. The in vivo studies confirmed biocompatibility of the implants in the surrounding tissue environment. Both the pure ABS and nanosilver-modified ABS implants exhibited a distinct decrease in the area of granulation tissue which was replaced with the regenerating muscle tissue.
Moreover, a slightly smaller area of granulation tissue was observed in the surroundings of the silver-doped prosthesis than in the case of pure ABS prosthesis. Our results showed that middle ear implant with the nanoscale modification is biocompatible and might be used in ossicular reconstruction.
Abstract Heavy metal pollution has long been the focus of attention because of its serious threat to human health and the environment. Surface enhanced Raman spectroscopy SERS has shown great potential for metal detection owing to many advantages, including, requiring fewer samples, its minimal [ Heavy metal pollution has long been the focus of attention because of its serious threat to human health and the environment. Surface enhanced Raman spectroscopy SERS has shown great potential for metal detection owing to many advantages, including, requiring fewer samples, its minimal damage to specimen, and its high sensitivity.
This SERS sensor could achieve an ultralow limit of detection 1. Khan , Ahmad Almatroudi and Kashif Raees. Abstract The objective of the present study was one step extracellular biosynthesis of silver nanoparticles AgNPs using supernatant of Candida glabrata isolated from oropharyngeal mucosa of human immunodeficiency virus HIV patients and evaluation of their antibacterial and antifungal potential against human pathogenic bacteria and [ The objective of the present study was one step extracellular biosynthesis of silver nanoparticles AgNPs using supernatant of Candida glabrata isolated from oropharyngeal mucosa of human immunodeficiency virus HIV patients and evaluation of their antibacterial and antifungal potential against human pathogenic bacteria and fungi.
The FTIR spectra revealed the binding and stabilization of nanoparticles with protein. The TEM analysis showed that nanoparticles were well dispersed and predominantly spherical in shape within the size range of 2—15 nm. These differences in bactericidal and fungicidal concentrations of the AgNPs were due to the differences in the cell structure and organization of bacteria and yeast cells.
The interaction of AgNPs with C. Further, TEM analysis showed that Candida cells treated with AgNPs were highly deformed and the cells had shrunken to a greater extent because of their interaction with the fungal cell wall and membrane, which disrupted the structure of the cell membrane and inhibited the normal budding process due to the destruction and loss of membrane integrity and formation of pores that may led to the cell death.
Abstract Magnetic nanoparticles offer multiple utilization possibilities in biomedicine. In this context, the interaction with cellular structures and their biological effects need to be understood and controlled for clinical safety.
Magnetic nanoparticles offer multiple utilization possibilities in biomedicine. The cellular internalization of nanoparticles was dependent on their dispersion in culture medium and caused some changes of F-actin filaments organization after 72 h. We concluded that in vitro biological responses to coated hybrid Fe-Si nanoparticles depended on particle synthesis conditions, surface coating, doses and incubation time. Control represents untreated cells. Failure to attend any test or submit the exercises before the deadline will result in a mark of zero in the corresponding continuous evaluation block see below.
Deadlines and test dates will be announced at least one week in advance. The minimum score in the final exam to pass the subject is 4 over 10, notwithstanding the mark obtained in continuous evaluation. Plagiarism, cheating or other acts of academic dishonesty will not be tolerated. Any infractions whatever will result in a failing grade. Basic Bibliography. Textbook of Nanocience and Nanotechnology.
Springer University Press. Drug Delivery Nanosystems for Biomedical Applications.
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Additional Bibliography. Rinaldi Editors. Nanobioelectronics - for Electronics, Biology and Medicine. Nanostructure Science and Technology Series, Springer. Lee, L. James Lee Editors.